Can D3 and K2 Help Stop Leg Cramps? Here’s What the Research Says

If you have ever been woken up in the middle of the night by a searing leg cramp to dealing with lingering muscle tension after working out, you’re far from the only one. Leg cramps are all too common, whether during the night, during workouts or as we age. Most of us try to soothe these symptoms by grabbing potassium or magnesium, but new research shows that the remedy might be a hard-hitting vitamin pair: Vitamin D3 and Vitamin K2.

What Causes Leg Cramps?

The cause of leg cramps can vary: dehydration, an electrolyte imbalance, overdoing it, or bad circulation. Yet one often overlooked offender, is a poor handling of calcium in the body.

When calcium is not absorbed or directed to where it should go, such as in muscles and bones, it can accumulate in soft tissues, causing stiffness, spasms and painful cramps. That’s where D3 and K2 come in.

How Vitamin D3 and K2 Work Together to Stop Cramps

Vitamin D3 is crucial in assisting your body absorb calcium from the food you consume. But boosting calcium absorption is only half the battle. Without sufficient Vitamin K2, that calcium might not go where it should. Instead, it may get lodged in arteries or muscular tissues, where it can actually do more harm than good.

Think of it like this: D3 is the gate and calcium is the door to your bloodstream. K2 is the traffic cop, directing that calcium to your bones and muscles and away from regions where it can be mischievous.

Clinical Study: Vitamin K2 for Nighttime Leg Cramps

An recent clinical study published in JAMA Internal Medicine found that subjects taking MK-7 (a form of Vitamin K2) experienced dramatically fewer nighttime leg cramps—almost 2.7 fewer episodes per week. And the cramps thatoccurred were smaller and less intense.

The key takeaway? K2 assisted in optimizing calcium use in the body, clearing the accumulation that can set off painful spasms. But in order for all of that to act, D3 has to be there as well.

How D3 + K2 Support Muscle Function and Recovery

When combined, D3 and K2 can help support:

  • Proper calcium absorption and distribution
  • Reduced muscle cramps and spasms
  • Stronger bones and better muscle function
  • Improved cardiovascular and circulatory health

What About Restless Leg Syndrome (RLS)?

Person's legs covered by a blanket on a bed.

Restless Leg Syndrome is a neurological condition that causes an uncontrollable urge to move the legs and is commonly described as tingling or uncomfortable sensations. It’s sometimes confused with nighttime leg cramps, but the two are pretty distinct from each other.

While D3 and K2 may not be a direct solution for RLS, some research suggests that low levels of Vitamin D are more common in people with RLS symptoms. If you’re experiencing frequent discomfort in your legs at night, try checking out your vitamin levels and nutrient balance, this may be a good first step.

Organic Vegan Vitamin D3 + K2

50MCG (5000IU) organic vegan vitamin D3 derived from algae with 50MCG K2 for immune support and bone health.

How PlantFusion Supports Muscle Health with D3, K2, and Calcium

At PlantFusion, we offer two ways to get the powerful benefits of D3 and K2:

  • Organic Vegan Vitamin D3 + K2: A simple, plant-based daily dose that gives your body what it needs to help route calcium to the right places—supporting stronger muscles, bones, and better recovery.
  • Vegan Plant-Based Calcium: A comprehensive formula with calcium from Icelandic red algae, plus magnesium, Vitamin D3, and K2. This full-spectrum approach supports bone density, reduces cramping, and aids calcium metabolism.

If you are struggling with restless nights, sore calves after long walks, or post-workout muscle tension, PlantFusion's D3 + K2 and PlantFusion’s Calcium could be the fix your body has been waiting for.

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