In a matter of months, Urolithin A has gone from being the obscure subject of research papers to becoming a headline talking point on major health and wellness podcasts. With a retail price that’s more than triple the average supplement, the big question on everyone’s mind is………. what is this exotic nutrient and what will it do for me?
In short, Urolithin A is nothing like the basic vitamins and minerals people take to fill gaps in their diet. It acts on the machinery that generates energy in your cells, promoting the natural turnover of NAD through recycling and contributing to healthy levels of NADH for more replenishing sleep and optimum daily energy. † Unlike most of the other supplements on the longevity shelf, this one actually has clinically-verified human results, not just lab markers. In one study, middle-aged adults taking this for four months had about a 12% increase in muscle strength (Singh et al., Cell Reports Medicine, 2022); and in another trial on older adults aged 65 to 90 taking this nutrient for four months demonstrated an increase in muscle endurance (Liu et al., JAMA Network Open, 2022).
That is the case for it. But before you jump in and try it yourself, here are five questions worth answering………..
So What Is Urolithin A?
This is not something that you’ll get in your diet. When you eat pomegranates, walnuts, or berries, you take in ellagic acid and ellagitannins. Specific gut bacteria convert those into Urolithin A, which is what your body actually uses.
Consider the pomegranate as raw material and Urolithin A as the finished product. Taking a Urolithin A supplement essentially bypasses the production process and delivers you a ready form of the compound directly into your system.
If It Comes From Pomegranates, Why Not Just Eat More of Them?
Unfortunately, the conversion of ellagic acid to Urolithin A is not something that you can control. In fact, it’s estimated that only one-third of the population has the gut bacteria needed to produce significant levels of Urolithin A from foods, and no amount of pomegranate juice changes your microbiome profile.
This single fact is why this category exists. Eating the precursor gets you a small fraction of what you think you are getting if you're if you’re among the majority.
What Dosage of Urolithin A Should I Be Taking?
This is a situation where you want to be extremely careful not to waste your time with proprietary blends that don’t disclose dosage or with products that have “window dressing” potencies just so that they can claim the ingredient on their label. In the initial human trial (Andreux et al., Nature Metabolism, 2019), Urolithin A was tested at 250mg, 500mg and 1,000mg daily with results showing that it is safe and well tolerated at each dosage. The strength and endurance trials above were run at 500mg and 1,000mg.
Therefore, 500mg is the minimum practical potency. Anything less is well below the range that human research has used.
How Can I Be Sure The Bottle Meets Label Claim?
Unless the brand can verify it, you can't. An independent analysis of ten popular urolithin A products found that six failed to deliver the dose advertised on the label. More recently, the federal courts banned 19 online sellers of fake Urolithin A supplements. Bottom line……..whenever you’re purchasing a supplement this expensive, you want to stick with a company that has a reputation that spans decades, not months.
Beyond that, you want to look for published third-party batch results that verify a 98% or higher purity. This isn’t some cheap mass market vitamin C supplement. If you’re seeing "premium quality" language with no verification, that’s a major red flag!
How Long Before Urolithin A Starts To Work?
Longer than most people expect. The functional results did not manifest until 2-4 months even though experimental molecular changes were perceived as early as four weeks in this study. In order to start seeing the kind of results that were experienced in the studies, you’ll want to make sure that you’re committing to at least a 60-90 day daily intake schedule.
This is one of those supplements you don’t want to judge before you have given it an entire cycle.
Why Should I Buy PlantFusion Urolithin A?
Every single-capsule serving of PlantFusion Urolithin A contains 500mg of the compound (the same dose as used in human clinical trials) plus 50mg of pomegranate extract standardized to 40% ellagic acid. Each batch of raw material is tested by accredited labs to ensure an absolute minimum 98% purity standard. And all third-party test results are published so that you know that what you paid for is exactly what you’re getting.
Buying a new supplement from a company you've never heard of is a major gamble. PlantFusion isn't that company. Long before Urolithin A became a headline, PlantFusion was a pioneer in plant-based nutrition across protein, collagen, vitamins, and minerals since 2009. And we back every bottle with our satisfaction guarantee.
